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Update parameter estimates (and fix)

update_parameters.Rd

For example for using model in simulations.

Usage

update_parameters(model, fit, fix = FALSE, verbose = FALSE)

Arguments

model

pharmpy model object or NONMEM model code (character) or path to NONMEM model file.

fit

pharmpy fit object

fix

fix the estimates?

verbose

verbose output?

Value

the input pharmpy model with parameter estimates updated, or invisible(NULL) if no estimates were available

Details

Supports both NONMEM-backend and nlmixr-backend pharmpy models. The fit argument may be:

  • a pharmpy ModelfitResults object (NONMEM path)

  • the pharmpy-shaped wrapper returned by run_nlme() on an nlmixr model

  • a raw nlmixr2FitCore object (output of nlmixr2::nlmixr2() called directly, without going through run_nlme())

For nlmixr2 fits, both diagonal and off-diagonal omega elements are extracted so that block-omega parameters (named IIV_X_IIV_Y in pharmpy) are updated alongside the variance terms.