Set scaling for certain compartments, e.g. dose and observation compartments.

Currently not available in Pharmpy, this is a workaround function.

Usage

set_compartment_scale(
  model,
  compartment = NULL,
  expression = list(variable = "V", scale = 1000),
  update_inits = TRUE,
  verbose = TRUE
)

model: pharmpy model object or NONMEM model code (character) or path to NONMEM model file.
compartment: compartment number. If NULL will be attempted to infer from ADVAN. If not a default ADVAN is used, will use 1 as default. So for safe use, please always specify the observation compartment to be scaled.
expression: specification of new scaling, should always contain variable and scale arguments. E.g. list(variable = "V", "scale" = 1000).
update_inits: update initial estimates for basic PK parameters? This is likely needed when applying scale, or else it is very likely that the model starts too far off from the maximum likelihood and the fit will not converge properly. TRUE by default.
verbose: verbose output?

Pharmpy model