Skip to contents

Calculate AKI stage

Source: R/calc_aki_stage.R
calc_aki_stage.Rd

Calculate AKI class based on serum creatinine values over time, using various methods for children (pRIFLE) and adults (RIFLE, kDIGO)

Usage

calc_aki_stage(
  scr = NULL,
  times = NULL,
  method = "kdigo",
  baseline_scr = "median",
  baseline_egfr = NULL,
  first_dose_time = NULL,
  age = NULL,
  egfr = NULL,
  egfr_method = NULL,
  force_numeric = FALSE,
  override_prifle_baseline = FALSE,
  verbose = TRUE,
  return_object = TRUE,
  ...
)

Arguments

scr

serum creatinine in mg/dL. Use convert_creat() to convert from mmol/L. Values below the detection limit ("<0.2") will be converted to numeric (0.2)

times

creatinine sample times in hours

method

classification method, one of KDIGO, RIFLE, pRIFLE (case insensitive)

baseline_scr

baseline serum creatinine, required for RIFLE classifation. Will use value if numeric. If character, can be either median, median_before_treatment, lowest, or first.

baseline_egfr

baseline eGFR, required for RIFLE classifations. Will take median of egfr values if NULL.

first_dose_time

time in hours of first dose relative to sCr value, used for calculate baseline serum creatinine in median_before_treatment approach.

age

age in years, needed when eGFR is used in the classification method

egfr

eGFR in ml/min/1.73m^2. Optional, can also be calcualted if age, weight, height, sex, egfr_method are specified as arguments.

egfr_method

eGFR calculation method, used by calc_egfr(). If NULL, will pick default based on classification system (cockroft_gault for RIFLE / kDIGO, revised_schwartz for pRIFLE).

force_numeric

keep stage numeric (1, 2, or 3), instead of e.g. "R", "I", "F" as in RIFLE. Default FALSE.

override_prifle_baseline

by default, pRIFLE compares eGFR to 120 ml/min. Override by setting to TRUE.

verbose

verbose (TRUE or FALSE)

return_object

return object with detailed data (default TRUE). If FALSE, will just return maximum stage.

...

arguments passed on to calc_egfr()

References

  • pRIFLE: Ackan-Arikan et al. "Modified RIFLE criteria in critically ill children with acute kidney injury." Kidney Int. (2007)

  • RIFLE: Bellomo et al. "Acute renal failure - definition, outcome measures, animal models, fluid therapy and information technology needs: the Second International Consensus Conference of the Acute Dialysis Quality Initiative (ADQI) Group." Critical Care. (2004)

  • KDIGO: Khwaja. "KDIGO clinical practice guidelines for acute kidney injury." Nephron Clinical Practice. (2012)

  • pRIFLE baseline eGFR: Soler et al. "pRIFLE (Pediatric Risk, Injury, Failure, Loss, End Stage Renal Disease) score identifies Acute Kidney Injury and predicts mortality in critically ill children : a prospective study." Pediatric Critical Care Medicine. (2014)

Examples

calc_aki_stage(
  scr = c(0.7, 0.9, 1.8, 1.5),
  t = c(0, 40, 100, 130),
  age = 50, weight = 60,
  height = 170, sex = "female")
#> No baseline SCr value specified, using *median* of supplied values.
#> Creatinine unit not specified, assuming mg/dL.
#> Warning: No baseline eGFR value specified, using median of supplied values.
#> Please note: Urinary output is not taken into account in staging.
#> $stage
#> [1] "stage 1"
#> 
#> $time_max_stage
#> [1] 100
#> 
#> $data
#>   scr   t deltat baseline_scr baseline_scr_diff baseline_scr_reldiff stage
#> 1 0.7   0      0          1.2              -0.5           -0.4166667    NA
#> 2 0.9  40     40          1.2              -0.3           -0.2500000    NA
#> 3 1.8 100     60          1.2               0.6            0.5000000     1
#> 4 1.5 130     30          1.2               0.3            0.2500000    NA
#>       egfr baseline_egfr_diff baseline_egfr_reldiff
#> 1 92.95488           35.11629             0.6071429
#> 2 72.29824           14.45965             0.2500000
#> 3 36.14912          -21.68947            -0.3750000
#> 4 43.37894          -14.45965            -0.2500000
#> 
#> $method
#> [1] "kdigo"
#>