Calculate AKI class based on serum creatinine values over time, using various methods for children (pRIFLE) and adults (RIFLE, kDIGO)
Usage
calc_aki_stage(
scr = NULL,
times = NULL,
method = "kdigo",
baseline_scr = "median",
baseline_egfr = NULL,
first_dose_time = NULL,
age = NULL,
egfr = NULL,
egfr_method = NULL,
force_numeric = FALSE,
override_prifle_baseline = FALSE,
verbose = TRUE,
return_object = TRUE,
...
)Arguments
- scr
serum creatinine in mg/dL. Use `convert_creat()` to convert from mmol/L. Values below the detection limit ("<0.2") will be converted to numeric (0.2)
- times
creatinine sample times in hours
- method
classification method, one of `KDIGO`, `RIFLE`, `pRIFLE` (case insensitive)
- baseline_scr
baseline serum creatinine, required for `RIFLE` classifation. Will use value if numeric. If `character`, can be either `median`, `median_before_treatment`, `lowest`, or `first`.
- baseline_egfr
baseline eGFR, required for `RIFLE` classifations. Will take median of `egfr` values if `NULL`.
- first_dose_time
time in hours of first dose relative to sCr value, used for calculate baseline serum creatinine in `median_before_treatment` approach.
- age
age in years, needed when eGFR is used in the classification method
- egfr
eGFR in ml/min/1.73m^2. Optional, can also be calcualted if `age`, `weight`, `height`, `sex`, `egfr_method` are specified as arguments.
- egfr_method
eGFR calculation method, used by `calc_egfr()`. If NULL, will pick default based on classification system (`cockroft_gault` for RIFLE / kDIGO, `revised_schwartz` for pRIFLE).
- force_numeric
keep stage numeric (1, 2, or 3), instead of e.g. "R", "I", "F" as in RIFLE. Default `FALSE`.
- override_prifle_baseline
by default, `pRIFLE` compares eGFR to 120 ml/min. Override by setting to TRUE.
- verbose
verbose (`TRUE` or `FALSE`)
- return_object
return object with detailed data (default `TRUE`). If `FALSE`, will just return maximum stage.
- ...
arguments passed on to `calc_egfr()`
References
pRIFLE: Ackan-Arikan et al. "Modified RIFLE criteria in critically ill children with acute kidney injury." Kidney Int. (2007)
RIFLE: Bellomo et al. "Acute renal failure - definition, outcome measures, animal models, fluid therapy and information technology needs: the Second International Consensus Conference of the Acute Dialysis Quality Initiative (ADQI) Group." Critical Care. (2004)
KDIGO: Khwaja. "KDIGO clinical practice guidelines for acute kidney injury." Nephron Clinical Practice. (2012)
pRIFLE baseline eGFR: Soler et al. "pRIFLE (Pediatric Risk, Injury, Failure, Loss, End Stage Renal Disease) score identifies Acute Kidney Injury and predicts mortality in critically ill children : a prospective study." Pediatric Critical Care Medicine. (2014)
Examples
calc_aki_stage(
scr = c(0.7, 0.9, 1.8, 1.5),
t = c(0, 40, 100, 130),
age = 50, weight = 60,
height = 170, sex = "female")
#> No baseline SCr value specified, using *median* of supplied values.
#> Creatinine unit not specified, assuming mg/dL.
#> Warning: No baseline eGFR value specified, using median of supplied values.
#> Please note: Urinary output is not taken into account in staging.
#> $stage
#> [1] "stage 1"
#>
#> $time_max_stage
#> [1] 100
#>
#> $data
#> scr t deltat baseline_scr baseline_scr_diff baseline_scr_reldiff stage
#> 1 0.7 0 0 1.2 -0.5 -0.4166667 NA
#> 2 0.9 40 40 1.2 -0.3 -0.2500000 NA
#> 3 1.8 100 60 1.2 0.6 0.5000000 1
#> 4 1.5 130 30 1.2 0.3 0.2500000 NA
#> egfr baseline_egfr_diff baseline_egfr_reldiff
#> 1 92.95488 35.11629 0.6071429
#> 2 72.29824 14.45965 0.2500000
#> 3 36.14912 -21.68947 -0.3750000
#> 4 43.37894 -14.45965 -0.2500000
#>
#> $method
#> [1] "kdigo"
#>