Function reference • clinPK

Anthropomorphic equations

calc_bsa(): Calculate body surface area

calc_ffm(): Calculate fat-free mass

calc_bmi(): Calculate BMI

calc_ibw() ibw_standard() ibw_devine(): Calculate ideal body weight in kg for children and adults

calc_lbw(): Calculate lean body weight

calc_abw(): Calculate adjusted body weight (ABW)

calc_dosing_weight(): Calculate commonly used "dosing weight"

calc_baseline_scr(): Calculate baseline sCr

pct_weight_for_age(): Percentile weight for age for children

pct_height_for_age(): Percentile height for age for children

pct_bmi_for_age(): Percentile BMI for age for children

Clinical chemistry

calc_egfr(): Calculate eGFR

calc_egfr_cystatin(): Calculate eGFR based on Cystatin C measurements

calc_kgfr(): Calculate kinetic GFR

calc_creat(): Estimate serum creatinine

calc_creat_neo(): Estimate serum creatinine in neonates

calc_aki_stage(): Calculate AKI stage

calc_neutropenia_grade(): Calculate neutropenia grade from ANC

Conversions

kg2lbs(): Convert kg to lbs

lbs2kg(): Convert lbs to kg

kg2oz(): Convert kg to oz

oz2kg(): Convert oz to kg

weight2kg(): Convert any weight unit to kg

cm2inch(): Convert cm to inch

inch2cm(): Convert inch to cm

conc2mol(): Convert concentration to molar

mol2conc(): Convert molar to concentration

absolute2relative_bsa(): Convert quantity expressed in absolute units relative to normalized BSA

relative2absolute_bsa(): Convert quantity expressed relative to BSA to absolute units

convert_flow_unit(): Convert flow (e.g. clearance) from / to units

convert_albumin_unit(): Convert albumin from / to units

convert_creat_assay(): Convert serum creatinine from various assays to Jaffe

convert_creat_unit(): Convert creatinine to different unit

convert_bilirubin_unit(): Convert bilirubin from / to units

PK compartmental equations

Functions to simulate concentrations for linear PK models.

pk_1cmt_inf(): Concentration predictions for 1-compartmental PK model after single or multiple bolus doses

pk_1cmt_inf_ss(): Concentration predictions for 2-compartmental PK model with infusion dosing at steady state

pk_1cmt_inf_cmin_ss(): Cmin (trough) for linear 1-compartment PK model at steady state

pk_1cmt_inf_cmax_ss(): Cmax for linear 1-compartment PK model at steady state

pk_2cmt_inf(): Concentration predictions for 2-compartmental PK model, single or multiple infusions

pk_2cmt_inf_ss(): Concentration predictions for 2-compartmental PK model with infusion dosing at steady state

pk_2cmt_inf_cmin_ss(): Cmin (trough) for 2-compartmental PK model, bolus dosing at steady state

pk_2cmt_inf_cmax_ss(): Cmax (trough) for 2-compartmental PK model, bolus dosing at steady state

pk_1cmt_bolus(): Concentration predictions for 1-compartmental PK model after single or multiple bolus doses

pk_1cmt_bolus_ss(): Concentration predictions for 1-compartmental PK model with bolus dosing at steady state

pk_1cmt_bolus_cmin_ss(): Cmin (trough) for linear 1-compartment PK model at steady state, bolus dosing

pk_1cmt_bolus_cmax_ss(): Cmax for linear 1-compartment PK model at steady state, bolus dosing

pk_1cmt_t12(): Calculate terminal half-life for 1-compartment model

pk_1cmt_oral(): Concentration predictions for 1-compartmental oral PK model after single or multiple bolus doses

pk_2cmt_bolus(): Concentration predictions for 2-compartmental PK model, single or multiple bolus doses

pk_2cmt_bolus_ss(): Concentration predictions for 2-compartmental PK model, bolus dosing at steady state

pk_2cmt_bolus_cmin_ss(): Cmin (trough) for 2-compartmental PK model, bolus dosing at steady state

pk_2cmt_bolus_cmax_ss(): Cmax for 2-compartmental PK model, bolus dosing at steady state

pk_2cmt_t12(): Calculate half-life(s) for 2-compartment model

pk_2cmt_t12_interval(): Calculate average half-life for 2-compartment model during a specific interval

PK steady state equations

accumulation_ratio(): Calculate accumulation ratio This is the ratio of drug concentration or AUC at steady state over concentrations after single dose

fraction_of_ss(): Calculate fraction of steady state at particular time after start of dosing

time_to_ss(): Time to steady state In either time units or number of doses

Dose/TDM calculations

Functions to calculate the dose expected to achieve a specific target exposure.

pk_1cmt_inf_dose_from_cmin(): Calculate dose to achieve steady state trough for 1-compartmental PK model with infusion dosing at steady state

pk_1cmt_bolus_dose_from_cmin(): Calculate dose to achieve steady state trough for 1-compartmental PK model bolus dosing at steady state

pk_2cmt_inf_dose_from_cmin(): Calculate dose to achieve steady state trough for 2-compartmental PK model with infusion dosing at steady state

pk_2cmt_bolus_dose_from_cmin(): Calculate dose to achieve steady state trough for 2-compartmental PK model bolus dosing at steady state

pk_1cmt_inf_dose_from_cmax(): Calculate dose to achieve steady state Cmax for 1-compartmental PK model with infusion dosing at steady state

pk_1cmt_bolus_dose_from_cmax(): Calculate dose to achieve steady state Cmax for 1-compartmental PK model bolus dosing at steady state

pk_2cmt_inf_dose_from_cmax(): Calculate dose to achieve steady state Cmax for 2-compartmental PK model with infusion dosing at steady state

pk_2cmt_bolus_dose_from_cmax(): Calculate dose to achieve steady state Cmax for 2-compartmental PK model bolus dosing at steady state

pk_1cmt_inf_dose_for_range(): Calculate dose based on a given AUC24, Cmax, and Cmin, assuming 1-compartment model

dose2auc(): Convert dose to expected AUCinf or AUCt for 1 compartment linear PK model

auc2dose(): Convert AUCtau or AUCt to dose (for 1-compartment linear PK model)

Miscellaneous functions

nca(): Perform an NCA based on a NONMEM-style dataset

egfr_cov_reqs(): Returns parameters needed to calculate eGFR according to the method specified.

check_covs_available(): Checks whether required covariates for eGFR calculations are present

calc_carboplatin_calvert(): Calvert equation for carboplatin

calc_kel_single_tdm(): Calculate elimination rate when given a single TDM sample

calc_kel_double_tdm(): Calculate elimination rate when given two TDM samples

calc_t12(): Calculate half-life based on two points

calc_amts_for_conc(): Calculate the amounts in all compartments in a compartmental PK system based on a given concentration in the central compartment, and assuming steady state.

find_nearest_dose(): Generic function to calculate the dose nearest to a specific dose unit increment

find_nearest_interval(): Generic function to calculate the interval nearest to a possible dosing interval

read_who_table(): Read WHO growth tables

valid_units(): Valid units

add_ruv(): Add residual variability to data