Calculate elimination rate when given a single TDM sample — calc_kel_single_tdm • clinPK

Using iterative k_el calculation, and based on given Volume

Usage

calc_kel_single_tdm(
  dose = 1000,
  V = 50,
  t = 10,
  dv = 10,
  tau = 12,
  t_inf = 1,
  kel_init = 0.1,
  n_iter = 25,
  learn_rate = 0.2
)

Arguments

dose: dose amount
V: volume of distribution
t: time or time after dose
dv: observed value
tau: dosing interval
t_inf: infusion time
kel_init: estimate of elimination rate
n_iter: number of iterations to improve estimate of elimination rate
learn_rate: default is 0.2

Examples

calc_kel_single_tdm(dose = 1000, t = 18)
#> [1] 0.1563328