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Calvert equation for carboplatin

Source: R/calc_carboplatin_calvert.R
calc_carboplatin_calvert.Rd

The Calvert equation calculates a dose expected to bring the patient to the target AUC given their glomerular filtration rate (GFR). The original equation was developed on a data set of 18 individuals with GFR of 33-136 ml/min.

Usage

calc_carboplatin_calvert(target_auc, gfr = NULL, ...)

Arguments

target_auc

target AUC, in mg/ml-min, typically between 2-8 mg/ml-min

gfr

glomerular filtration rate, in ml/min. See also clinPK::calc_egfr.

...

arguments passed on to calc_egfr if gfr is not supplied

References

Calvert et al., Journal of Clinical Oncology (1976)

Examples

calc_carboplatin_calvert(5, 100)
#> [1] 700
calc_carboplatin_calvert(4, 30)
#> [1] 224
calc_carboplatin_calvert(2, sex = "male", age = 50, scr = 1.1, weight = 70)
#> Creatinine unit not specified, assuming mg/dL.
#> [1] 230.9091