Calculate Cefepime-associated Neurotoxicity

Calculate probability of cefepime-associated neurotoxicity as a function of cefepime plasma trough concentrations. This model was based on a data set of adult patients receiving thrice-daily cefepime and may not correspond to other dosing intervals or patient populations.

Usage

calc_cefepime_neurotoxicity(trough_concentration)

Arguments

trough_concentration

Cefepime plasma trough concentration (mg/L).

Value

Probability of cefepime-associated neurotoxicity.

Note

The intercept and slope used in this function match Figure 2 in the cited paper, but differ slightly from the values provided in the text. This interpretation was confirmed via correspondence with the authors.

References

Boschung-Pasquier et al., Clinical Microbiology and Infection (2020)

Examples

calc_cefepime_neurotoxicity(trough_concentration = c(13.7, 17.8))
#> [1] 0.2498005 0.5002675