Calculate probability of therapeutic success for treosulfan as a function of
cumulative AUC. This model was based on a data set of children receiving
treosulfan once daily for 3 days and may not correspond to other dosing
intervals or patient populations.
Usage
calc_treosulfan_success(cumulative_auc)
Arguments
- cumulative_auc
Cumulative AUC mg hour/L.
Value
Probability of therapeutic success for treosulfan.
Note
The parameter estimates used in this function match Figure 3a in the cited
paper, but differ slightly from the values provided in Table 2, which were
rounded. The decimal values used here were solved for using results cited in
the paper, and are close but not an exact match.
Examples
calc_treosulfan_success(c(3863, 4800, 4829, 6037))
#> [1] 0.7864854 0.8171991 0.8172208 0.7864636
curve(
calc_treosulfan_success,
from = 2000,
to = 15000,
log = "x",
ylim = c(0, 1),
xlab = "Cumulative AUC",
ylab = "P(Success)"
)
