Create scheme for updating dose or interval during dose optimization trial

Usage

create_regimen_update_design(
  at,
  anchor,
  update_type = c("dose", "interval"),
  dose_optimization_method = map_adjust_dose
)

Arguments

at: numeric vector of the dose or day number to "anchor" the sampling times to. Vector needs to be of same length as time. If anchor is set to day, then the first dose in that day is used. If later doses in the day are preferred, the anchor can also be specified fractionally, e.g. 1.5 will use the time of the first dose in the second half of the 1st day.
anchor: either day or dose. Single value required, i.e. anchor types cannot be mixed.
update_type: update either future dose (default) or interval.
dose_optimization_method: A function that determines how doses should be adjusted given the collected drug levels. The function must return a named list of the structure list(regimen = reg, additional_info = x), where reg is the updated PKPDsim regimen for the patient and x can be another other information useful for post-processing of trial results.

Examples

create_regimen_update_design(
  at = c(2, 5, 8),
  anchor = "dose"
)
#> $dose_optimization_method
#> function (tdms, est_model, parameters, omega, ruv, regimen, covariates = NULL, 
#>     target_design, dose_update, grid = NULL, ...) 
#> {
#>     est_par <- simulate_fit(est_model = est_model, parameters = parameters, 
#>         omega = omega, ruv = ruv, tdms = tdms, covariates = covariates, 
#>         regimen = regimen, ...)
#>     if (is.null(grid)) {
#>         d1 <- regimen$dose_amts[1]
#>         grid <- seq(d1/5, d1 * 5, length.out = 10)
#>     }
#>     new_dose <- dose_grid_search(est_model = est_model, regimen = regimen, 
#>         parameters = est_par, target_design = target_design, 
#>         auc_comp = PKPDsim::get_model_auc_compartment(est_model), 
#>         dose_update = dose_update, grid = grid, grid_type = "dose", 
#>         covariates = covariates, iov_bins = PKPDsim::get_model_iov(est_model)$bins, 
#>         ...)
#>     regimen <- update_regimen(regimen, new_dose = new_dose, dose_update_number = dose_update)
#>     list(regimen = regimen, dose_update = dose_update, new_dose = new_dose, 
#>         new_interval = NA, additional_info = est_par)
#> }
#> <bytecode: 0x557c6d68cec0>
#> <environment: namespace:mipdtrial>
#> 
#> $scheme
#>   base offset at anchor scatter update_type
#> 1 dose      0  2   dose       0        dose
#> 2 dose      0  5   dose       0        dose
#> 3 dose      0  8   dose       0        dose
#> 
create_regimen_update_design(
  at = c(4, 8),
  anchor = "day",
  update_type = "interval",
  dose_optimization_method = map_adjust_interval
)
#> $dose_optimization_method
#> function (tdms, est_model, parameters, omega, ruv, regimen, covariates = NULL, 
#>     target_design, dose_update, grid = NULL, ...) 
#> {
#>     est_par <- simulate_fit(est_model = est_model, parameters = parameters, 
#>         omega = omega, ruv = ruv, tdms = tdms, covariates = covariates, 
#>         regimen = regimen, ...)
#>     if (is.null(grid)) {
#>         stop("Interval-optimization requires `grid` argument.")
#>     }
#>     new_interval <- dose_grid_search(est_model = est_model, regimen = regimen, 
#>         parameters = est_par, target_design = target_design, 
#>         auc_comp = PKPDsim::get_model_auc_compartment(est_model), 
#>         dose_update = dose_update, grid = grid, grid_type = "interval", 
#>         covariates = covariates, iov_bins = PKPDsim::get_model_iov(est_model)$bins, 
#>         verbose = T, ...)
#>     regimen <- update_regimen(regimen, new_interval = new_interval, 
#>         dose_update_number = dose_update)
#>     list(regimen = regimen, dose_update = dose_update, new_dose = NA, 
#>         new_interval = new_interval, additional_info = est_par)
#> }
#> <bytecode: 0x557c6d772628>
#> <environment: namespace:mipdtrial>
#> 
#> $scheme
#>   base offset at anchor scatter update_type
#> 1 dose      0  4    day       0    interval
#> 2 dose      0  8    day       0    interval
#>