Model-based starting dose — model_based_starting

A light wrapper for dose_grid_search for finding model-based starting doses and returning an appropriate regimen object.

Usage

model_based_starting_dose(design, covariates, cov_mapping, ...)

design: trial design, created using create_trial_design()
covariates: named list of PKPDsim covariates. E.g.: list(WT = PKPDsim::new_covariate(70))
cov_mapping: a named vector indicating correspondence between model covariates and data frame columns. Vector names should reflect all covariates defined by the model, and vector values should represent the associated column in the provided data set.
...: arguments passed on to dose_grid_search

Returns a PKPDsim regimen populated with the model-predicted dose