Simulate different doses/intervals in a dose/interval grid

Usage

simulate_dose_interval(
  value,
  grid_type = "dose",
  dose_update,
  regimen,
  parameters,
  covariates = NULL,
  md,
  pta,
  target_design,
  model,
  omega,
  obs,
  ruv,
  ...
)

Arguments

value: element of the dose/interval grid
grid_type: either dose grid or interval grid
dose_update: update dose from which dose?
regimen: PKPDsim regimen object
parameters: list of model parameters
covariates: covariates object
md: metadata object (only needed if we have to use get_quantity_from_variable() to generate target value)
pta: probability of target attainment, list with arguments type and value, also requires omega if non-NULL. If NULL, will just aim for specific conc or auc.
target_design: object specifying target design, created using function create_target_design()
model: model for simulating dose (estimation model)
omega: IIV matrix, for estimation model, for probability of target attainment target types.
obs: Value of obs as determined by dose_grid_search() (i.e. either "obs" or AUC compartment)
ruv: list specifying residual error for estimation model: list(prop = 0.1, add = 1.5), for probability of target attainment target types.
...: passed on to PKPDsim function