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Apply infusion duration scale to a regimen

Source: R/apply_duration_scale.R
apply_duration_scale.Rd

E.g. see Centanni et al. Clin Pharmacokinet 2024. An estimated scaling factor for the length of the infusion was applied there in a model for vincristine. This is likely most relevant for very short infusions.

Usage

apply_duration_scale(
  regimen,
  duration_scale = NULL,
  parameters = NULL,
  cmt_mapping = NULL
)

Arguments

regimen

PKPDsim regimen

duration_scale

infusion length scale.

parameters

parameter list, required if the duration scale is specified as a parameter.

cmt_mapping

map of administration types to compartments, e.g. `list("oral" = 1, "infusion" = 2, "bolus" = 2)`.

Value

Original regimen with infusion lengths scaled by a factor

Details

Implementation is similar to handling of `lagtime`, i.e. the regimen that is the input for the simulation function is updated.