E.g. see Centanni et al. Clin Pharmacokinet 2024. An estimated scaling factor
for the length of the infusion was applied there in a model for vincristine.
This is likely most relevant for very short infusions.
Usage
apply_duration_scale(
regimen,
duration_scale = NULL,
parameters = NULL,
cmt_mapping = NULL
)
Arguments
- regimen
PKPDsim regimen
- duration_scale
infusion length scale.
- parameters
parameter list, required if the duration scale is
specified as a parameter.
- cmt_mapping
map of administration types to compartments, e.g.
list("oral" = 1, "infusion" = 2, "bolus" = 2).
Value
Original regimen with infusion lengths scaled by a factor
Details
Implementation is similar to handling of lagtime, i.e. the regimen that is the
input for the simulation function is updated.