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Returns the state of a linear PK system at steady state (trough) using analytics equations (so for linear PK systems only).

Source: R/calc_ss_analytic.R
calc_ss_analytic.Rd

Basically it performs a PK simulation using analytic equations instead of ODEs to steady state (n=45 days, increased if needed).

Usage

calc_ss_analytic(
  f = "1cmt_oral",
  dose,
  interval,
  t_inf = NULL,
  model,
  parameters,
  covariates = NULL,
  map = NULL,
  n_days = 45,
  n_transit_compartments = 0,
  auc = FALSE
)

Arguments

f

analytic equation to use, must be one of names(advan_funcs)

dose

dose

interval

interval

t_inf

infusion time

model

PKPDsim model

parameters

parameters list

covariates

covariates list

map

list for remapping parameters, ex: list(CL = "CL", V = "V")

n_days

number of days at which to assume steady state. Default is 45.

n_transit_compartments

number of transit compartments, will insert n compartments between the first (dose) compartment and the second (central) compartment.

auc

add (empty) AUC compartment at end of state vector?

Value

State vector of a linear pharmacokinetic system at steady state

Details

It can also be used for models with transit compartments, however, the assumption is made that at the end of the dosing interval the amount in the transit compartments is negligible (0).