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Calculate model-specific variables using a dummy call to sim_ode()

Source: R/calculate_parameters.R
calculate_parameters.Rd

This is a convenience function for PKPDsim users, it is not used inside the sim_ode()`` function in any way. This function is useful for converting from an estimated parameter to actual parameter, e.g. when clearance is specified as CLi = CL * (WT/70) * (1/CR)it can be used to calculateCLi` without having to write that function a second time in R.

Usage

calculate_parameters(
  ode = NULL,
  parameters = NULL,
  covariates = NULL,
  include_parameters = TRUE,
  include_variables = TRUE,
  regimen = NULL,
  t_obs = NULL,
  ...
)

Arguments

ode

PKPDsim model object

parameters

parameter list

covariates

covariate list. Make sure to include covariates at the right time point, since only last observed covariate values are used.

include_parameters

boolean, include parameters?

include_variables

boolean, include variables?

regimen

optional, provide a regimen object for the computation of the effective parameters. This is only relevant for models for which parameters depend on the dose or administration type, which is rare.

t_obs

optional, provide timepoint(s) at which to computate effective parameters. This is only relevant for models with time-varying fixed-effects. If unspecified, will evaluate parameters at t=0.

...

arguments to pass on to simulation function

Value

List of model-specific variables