Create a dosing regimen for use with sim_ode
Usage
new_regimen(
amt = 100,
interval = NULL,
n = 3,
times = NULL,
type = NULL,
t_inf = NULL,
rate = NULL,
t_lag = NULL,
cmt = NULL,
checks = TRUE,
ss = FALSE,
n_ss = NULL,
first_dose_time = now_utc()
)Arguments
- amt
dosing amount, either a single value (which will repeated for multiple doses), or a vector with doses for each administration
- interval
dosing interval (requires n as argument)
- n
number of doses (requires interval as argument)
- times
vector describing dosing times. Overrides specified times using interval and n arguments
- type
either "infusion", "bolus", "oral", "sc" (subcutaneous), or "im" (intramuscular).
- t_inf
infusion time (if `type`==`infusion`)
- rate
infusion rate (if `type`==`infusion`). `NULL` by default. If specified, overrides `t_inf`
- t_lag
lag time (can be applied to any dose type, not only oral). Will just be added to `times`
- cmt
vector of dosing compartments (optional, if NULL will dosing compartment defined in model will be used)
- checks
input checks. Remove to increase speed (e.g. for population-level estimation or optimal design)
- ss
steady state? boolean value whether to simulate out to steady state first (steady state will be based on specified `amt` and `interval`, `times` will be ignored).
- n_ss
how many doses to simulate before assumed steady state. Default is 4 * 24 / `interval`.
- first_dose_time
datetime stamp of first dose (of class `POSIXct`). Default is current date time.