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Convert PKPDsim regimen to NONMEM table (doses only)

Source: R/regimen_to_nm.R
regimen_to_nm.Rd

Note: when bioavailability is used for insusions: NONMEM behaves differently from PKPDsim and Monolix, in that rates are not automatically recomputed for infusions where bioavailabiliy also applies. In PKPDsim/Monolix, for a bioavailability of 50%, an AMT of 100 mg and rate of 100mg/hr would be recalculated to 50 mg and 50 mg/hour, respectively, to keep the infusion length the same. This is not the case in NONMEM. Therefore, the easiest way to work around this is for the user to compute the rate manually in NONMEM using custom code. Therefore, we set the RATE column to -1 for such infusions.

Usage

regimen_to_nm(
  reg = NULL,
  dose_cmt = 1,
  n_ind = 1,
  t_obs = NULL,
  obs_cmt = 1,
  bioav = NULL
)

Arguments

reg

PKPDsim regimen, created using new_regimen() function

dose_cmt

dosing compartment, if not specified in reg object

n_ind

repeat for n_ind subjects

t_obs

add observation time(s)

obs_cmt

observation compartment for added observation time(s)

bioav

bioavailability (numeric vector, can not be a parameter)

Value

Data frame containing doses